Determining relations, or possible relationships, between family members will lead to a family secured from unanswerd questions or acquisitions. Paternity finds the bond between Mother, Farther and Child.
Chain of Custody Requirements
Chain of custody requirements must be fulfilled for test results to be defensible in any legal situation, such as inheritance disputes. These requirements include the following:
o Samples are collected by a neutral third party, such as a clinic or laboratory.
" The individuals tested are positively identified (i.e., they present a government-issued ID to be photocopied and/or they are photographed and fingerprinted).
o A standard DNA Diagnostics Center kit is used.
o Each party completes and signs a Client Identification and Consent Form (COC-4002).
Non-Chain of Custody Requirements
In a non-chain of custody test, samples are collected by the patients themselves. Results of this test are for personal knowledge only and may not be used for legal purposes.
. A Beta Genetics kit is used, and buccal samples can be collected by the patients themselves at a time and place that they choose.
. Since the origin of the samples cannot be verified, names are not listed on the report (i.e., the report will only show "Child," "Alleged Father," etc.)
o An RL kit number is assigned to each kit and will appear on the report as a reference for the case.
Paternity Test (Trio)
A standard paternity test, called a trio, involves the child, mother, and alleged father. The mother's participation is always encouraged in a paternity test.
Who needs to be tested?
One Mother, one Child, and one Alleged Father (AF)
Turnaround Time
3-5 business days from receipt of all samples
Notes
o The mother's participation is encouraged because we can identify the DNA she passed along to the child. By
process of elimination, the lab can identify the DNA the father has given to the child. The average Combined
Paternity Index (CPI) of a trio is 1 million, while the average CPI of a motherless case is only 10,000.
o A trio paternity test provides the strongest case for use in the courts, where the mother's involvement is
preferred and sometimes required.
o The mother's involvement allows her access to the case with questions or concerns, a copy of the paternity
results, and a full chain of custody if required.
o The mother is tested at no additional fee.
Paternity Test (Motherless):
Motherless Paternity Test
Because DNA testing is so powerful, paternity can be determined even when the mother is unwilling or unavailable to be tested.
Who needs to be tested?
One Child and one Alleged Father (AF)
Turnaround Time
3-5 business days from receipt of all samples
Note
If the mother is unwilling to be tested but can accompany the child to the collection, request that she provide consent for the minor child. Her signature and consent will provide her with access to the case with questions or concerns, a copy of the paternity results, and a full chain of custody.
Paternity Test with Related Alleged Fathers
If two alleged fathers are closely related (full brothers, half brothers, or father/son), their genetic structure can be similar, and they might share the same DNA markers commonly used in a DNA paternity test. Both could test positive as the child's biological father.
DNA testing is powerful enough to determine paternity even if the alleged fathers (AFs) are related, but you must notify our laboratory of this possibility before the testing begins. If there are two or more biologically related alleged fathers, you have three options.
Option 1:
Test all biologically related alleged fathers
The best scenario would be to test the child, the mother, and all biologically related alleged fathers at the same time to compare their DNA profiles with the child's DNA profile. When we have samples from each AF, less testing is required to achieve conclusive results. There will be an additional charge for each additional alleged father tested.
Option 2:
Test one alleged father with extended analysis
If only one alleged father is available for paternity testing, we can perform additional testing and statistical analyses to reach a conclusive result. We have an extended testing panel that allows us to test up to 9 additional markers. With this testing panel, we can either achieve an exclusion or provide a probability that the tested man is the biological father as opposed to the unavailable alleged father. There is an additional testing fee for extended testing and analysis; the turnaround time is 14 working days.
Option 3:
Test one alleged father without extended analysis
If you are unable to include the other alleged father in the paternity test, we can also run a standard paternity test; however, there is a possibility of false inclusion. The AF will be tested as only a random individual, so the results would include the following statement: "The paternity calculation does not take into consideration any biological relatives of the AF."
Prenatal Paternity Test
Paternity can be determined before birth through prenatal testing, which can be done during the 10th through the 24th week of gestation using amniocentesis or chorionic villi samples collected by an OB-GYN. The mother is required to give buccal swab samples in all prenatal tests.
Who needs to be tested?
Mother, Prenatal Sample, and one Alleged Father (AF)
Turnaround Time
5 business days from receipt of all samples
Notes
• CVS (chorionic villi sampling) is usually performed during the 10th-13th week of gestation. This is done either transcervically (through the vagina) or transabdominally (using a long needle through the abdomen).
• Amnio (amniocentesis) is usually performed during the 14th-24th week of gestation. The procedure involves drawing amniotic fluid from the sac surrounding and protecting the fetus. This fluid contains some viable (live) cells that have been shed by the fetus.
• Because both Amnio and CVS are invasive, the patient should speak with a physician about the risks involved in prenatal testing.
• Our fees do not include the OB-GYN fee for collecting the prenatal sample. This fee usually ranges between $500-$1,500. We have an OB-GYN referral service for patients who do not have access to an OB-GYN. The fee for this referral service is $200.
Post-Mortem Test
It is possible to perform DNA testing on deceased individuals using their stored samples. The post-mortem viability test is performed on a sample from a deceased individual to determine if the sample yields sufficient viable DNA to proceed with further testing. The fee for the viability test is separate from the paternity test fee. The fee varies according to the sample type, as specified in the Unusual Samples List (which appears in the first section of this manual).
Turnaround Time
5 business days from receipt of samples (bone and tooth samples require longer turnaround times)
Suggested Information to Be Obtained from Clients
o The date of autopsy, if an autopsy has been or will be performed
o Race of the deceased individual
o Type and quantity of available samples
o Storage method of available samples (e.g., frozen, refrigerated, or room temperature)
o Type of container the samples have been stored in (e.g. purple-top EDTA tube)
o The date and cause of death
o Name and phone number of the "next of kin" or estate attorney of the deceased
o Contact information for the facility in possession of the stored samples, and if it is willing to release
the samples. (Many medical examiners and hospitals require either a court order or written permission
from the next of kin before releasing a sample.)
Maternity Testing
A maternity test is performed to confirm the biological relationship between a mother and child-for example, in immigration cases, adoption, and hospital nurseries.
Who needs to be tested?
One Alleged Mother (AM) and one Child
Turnaround Time
3-5 business days from receipt of all samples
Genetic Reconstruction
Genetic reconstruction is used to test the relationship between a child and biological relatives of the alleged father, if he is deceased or unavailable for testing.
Who needs to be tested? - Option 1
One Mother, one Child, one Paternal Parent (PP) of the Alleged Father (AF), and one Full Sibling (FS) of the AF.
Who needs to be tested? - Option 2
One Mother, one Child, and two Full Siblings (FS) of the Alleged Father (AF).
Turnaround Time
14 business days frojji receipt of all samples
Notes
o There are several different scenarios for genetic reconstruction. An ideal situation would be to test the
mother, child, one parent of the deceased, and one or more full siblings of the deceased. We can also
perform the test if we have two full siblings of the deceased, the mother, and the child. For circumstances
other than these, please contact your account manager.
o In general, biological relationship testing (such as genetic reconstruction and siblingship testing) is not as
definitive as DNA parentage testing. It is not possible to determine with absolute certainty whether two
people are siblings or biologically related in some way other than the parent-child relationship.
o Results will show a Combined Relatedness Index, a statistical value showing the genetic odds in favor of
the relationship. This number represents the number of times that the tested individuals are more likely
than not to be biologically related in the manner being tested.